I-380 begins at an interchange with
I-80 in the northeastern corner of
Tunkhannock Township in
Monroe County, heading north as a four-lane
freeway. The road soon crosses into
Tobyhanna Township and runs through forested areas in the
Pocono Mountains with nearby development, passing west of the
Kalahari Resort and Convention Center. The highway comes to an interchange with
Pennsylvania Route 940 (PA 940) to the west of
Pocono Summit. I-380 continues north and crosses into
Coolbaugh Township, where it curves northwest and runs through dense forests. The road passes through part of Pennsylvania State Game Lands Number 127 before it comes to a northbound exit and southbound entrance at
PA 423 near
Tobyhanna. A short distance later, the highway comes to a southbound exit and northbound entrance serving the northern terminus of
PA 611. Following this interchange, I-380 passes to the southwest of
Tobyhanna Army Depot before it runs along the border between Pennsylvania State Game Lands Number 127 to the southwest and
Gouldsboro State Park to the northeast. Farther northwest, the highway comes to a
diamond interchange with the southern termini of
PA 435 and
PA 507 near
Gouldsboro. Immediately after the PA 435/PA 507 interchange, I-380 passes through a small corner of
Lehigh Township in
Wayne County before it crosses the
Lehigh River into
Clifton Township in
Lackawanna County. The highway continues through forested areas and curves to the north, passing a northbound
weigh station and crossing into
Covington Township. The freeway runs past a southbound weigh station and bends northwest again. The route curves back to the north into a mix of fields and woods and reaches a diamond interchange with
PA 307. Past this interchange, I-380 curves north into the borough of
Moscow and coming to a southbound exit and northbound entrance at
PA 690. The roadway curves northwest and passes through a corner of
Spring Brook Township before entering
Roaring Brook Township, where it runs through forests with nearby development and comes to an interchange with
I-84. At this point, I-84 and I-380 become
concurrent, with the freeway using I-84's exit numbers and mileposts. The two routes continue north through forested areas in the
Moosic Mountains, entering the borough of
Dunmore and coming to a bridge over
Roaring Brook and a
Delaware-Lackawanna Railroad line. After this bridge, the highway curves northwest and comes to a southbound exit and northbound entrance with the northern terminus of PA 435. The freeway widens to six lanes and winds through the mountains before it comes to an interchange with Tigue Street, at which point it runs past commercial development. A short distance later, I-84 and I-380 both come to their termini at an interchange with
I-81 and
US 6, with the freeway merging onto northbound I-81/westbound US 6. ==History==