Iowa 220 was created in the early 1930s as a
spur route from West Amana to Amana. By 1947, Iowa 220 ran from South Amana to Amana along the current extent of the route. However, the route continued east for where it ended at East Amana and south for to Upper South Amana. At its longest, the route was long. The western end of the route was pulled back to its current western end in 1976. Four years later, its eastern end was truncated back to the intersection with
Iowa 149 in Amana. In 1985, Iowa 149 was replaced by US 151 between
Cedar Rapids and
Interstate 80. ==Major intersections==