Ippolito was born in
Ferrara,
Italy, the second son of Duke
Alfonso I d'Este and
Lucrezia Borgia. His elder brother,
Ercole II d'Este, succeeded his father as
Duke of Ferrara in 1534. Through their mother, Ippolito and Ercole were grandsons of
Pope Alexander VI. Ippolito himself is named after his uncle, Cardinal
Ippolito d'Este. In 1519, at the age of 10, he inherited the
archbishopric of Milan from his uncle. This was the first of a long list of ecclesiastical
benefices which Ippolito was given over time, the revenue from which was his main source of income. In addition to Milan, at the end of his life, Ippolito also held the benefices of the sees/abbeys of Bondeno,
Chaalis (1540–1572),
Jumieges in Normandy, Lyon, Narbonne, and Saint-Médard in Soissons. Ippolito d'Este was created Cardinal of Santa Maria in Aquiro by
Pope Paul III in the consistory on 20 December 1538. He was ordained a priest in 1564. ==Patronage of the arts==