Real Betis In 2012, Guerrero joined the newly formed
Real Betis, the club she grew up supporting. She made her senior debut with the team while playing in the
second division. She made over 100 appearances for the club, helping earn promotion to the first division during the
2015–16 Segunda División. For the club's debut season in the
2016–17, Guerrero was named captain at the age of 19. She was the only player on the team to play in all 30 games and scored three goals at the team finished comfortably mid-table in 11th.
Levante In 2020, Guerrero was recruited by her former Betis coach María Pry who had joined
Levante UD the previous season. On 18 August 2021, she made her
UEFA Women's Champions League debut during the
first qualifying round, starting in a 2–1 victory over
Celtic.
Atlético Madrid She joined
Atlético Madrid in June 2022. On 27 May 2023, Guerrero won her first competitive senior trophy as Atlético Madrid lifted the
2022–23 Copa de la Reina, beating rivals
Real Madrid on penalties following a 2–2 draw. Guerrero was a 57th-minute substitute with Atlético trailing 2–0 and scored in the penalty shootout.
Manchester United In September 2023, she signed for
Manchester United. She made seven appearances in her time at the club.
Club América On 18 July 2024, Guerrero signed for
Liga MX Femenil side
Club América. ==International career==