Lankershim settled in
St. Louis,
Missouri and worked in the grain and livestock shipping business. In 1854, Lankershim moved west to the
Napa Valley in California. for US$115,000 together with other businessmen from San Francisco, known as the San Fernando Valley Farm Homestead Association. These acres included what is now
Woodland Hills,
Tarzana,
Encino,
Sherman Oaks,
Van Nuys and
North Hollywood. By 1873, they raised 40,000 sheep on the ranch. When wool prices fell, they grew wheat instead. To take the wheat from the valley to
Santa Monica, California, he built a wagon path, which he turned into a toll road in 1876. The route is followed by today's
Interstate 405. With his son-in-law,
Isaac Newton Van Nuys, Lankershim started the Los Angeles Farming and Milling Co, and they took over full ownership of the San Fernando Valley Ranch Company. They also established the Lankershim Ranch Land & Water Co., a 12,000-acre real estate development in what is now known as
North Hollywood, Los Angeles. ==Personal life, death and legacy==