Dr. Isaac Wiley commenced the practice of medicine in Western Pennsylvania, subsequently moving to
Pottsville in 1849. Shortly thereafter, at the request of Dr. Durbin, Isaac agreed to go as a medical missionary to
Fuzhou,
China. Isaac first was received into the ministry of the Genesee Annual Conference of the M.E. Church. He also attended an additional course of lectures in the University of New York. Finally, he sailed for
China, March 1850, transferring his conference membership to the
Philadelphia Conference. ==Pastoral, academic, and editorial ministries==