In 1960, Sanford withdrew money from her retirement fund, boarded a bus with her three children, left her husband in New York, and moved to Los Angeles. Soon after her arrival, she was asked to join the national production of
Here Today by actress
Tallulah Bankhead. She caught the attention of major Hollywood players, including
Norman Lear, who cast Sanford in the role of Louise Jefferson in
All in the Family. Sanford and her TV husband
Sherman Hemsley were so popular that Norman Lear decided to spin off the characters into their own weekly series
The Jeffersons. Sanford was initially reluctant to commit to working on a weekly series, as she was already working steadily, but decided to accept the offer.
The Jeffersons premiered in January 1975, and was an immediate hit with audiences, ultimately running for 11 seasons. In the 1990s, Sanford mainly appeared in television guest appearances and
cameo appearances in movies. She appeared on
Dream On,
Living Single, ''
Hangin' with Mr. Cooper, In the House, Lois & Clark: The New Adventures of Superman, The Steve Harvey Show, and Hearts Are Wild. In 1996, she played a supporting role in the action movie Original Gangstas'', starring
blaxploitation film stars
Fred Williamson,
Pam Grier,
Jim Brown, and
Richard Roundtree. Isabel Sanford appeared in Kojak Season 1 Episode 14 "Die Before They Wake" in 1974. Sanford later reprised her role as Louise Jefferson in a touring company of
The Real Live Jeffersons stage show in the mid-1990s alongside
Sherman Hemsley. She and Hemsley also made a cameo appearance in the film
Sprung, and guest-starred in
The Parkers,
Mafia!, and two episodes of
The Fresh Prince of Bel-Air. The two also appeared in a series of
advertisements for
Denny's and
Old Navy. ==Personal life==