María Isabel Riquelme de la Barrera y Meza was born on 6 March 1758 in
Chillán,
Captaincy General of Chile (present-day Chile) to Simón Riquelme de la Barrera y Goycochea, a
Mayor and
landowner, and María Mercedes de Mesa y Ulloa (died 1758). Riquelme's mother died during childbirth. Following a brief relationship, Riquelme became pregnant and gave birth to Bernardo O'Higgins in August 1778. On 1 June 1780, Riquelme married Félix Rodríguez y Rojas (died 1782) with whom she had
Rosa Rodríguez y Riquelme. Riquelme later began a relationship with Manuel de Puga y Figueroa in 1789, with whom she a daughter Maria de las Nieves de Puga y Riquelme (1790–1868). ==Chilean War of Independence==