Born in Kensington, Holmes was the daughter of chemist Dr
John Hall Gladstone. In 1887, she married Basil Holmes, a local politician in Ealing, west London, and Secretary of the Metropolitan Public Gardens Association. They lived in Ealing, and had five children, Edith, Marion, Wilfred, Stephen, and Edward. The family attended
St Peter's Church, Ealing, where Basil Holmes was a sidesman.
Stephen Holmes became High Commissioner for Australia from 1952 to 1956. Wilfred Gladstone Holmes died in 1913 while serving as a Second Lieutenant in the
Royal Garrison Artillery. He is memorialised in
St Peter's Church, Ealing, where the Lady Chapel altar rails were given in his memory, as well as at
Bradfield College. Isabella Holmes' half sister
Margaret Ethel Gladstone became the wife of
Ramsay MacDonald, Britain's first Labour Prime Minister. ==See also==