Not much is known about Isabella's life. She was the daughter of the reigning Duke of Bourbon, and his Burgundian wife, Agnes, daughter of
John the Fearless, the powerful
Duke of Burgundy. Although her father was politically opposed to his brother-in-law,
Philip the Good, he betrothed Isabella to
Charles the Bold, only legitimate son and heir of Burgundy as a condition of truce. She married Charles on 30 October 1454 at Lille, France, and they were reportedly very much in love, perhaps because of (or causing) her husband's faithfulness. In 1459, Isabella stood godmother to Joachim, the short-lived son of the refugee
Dauphin of France and his second wife,
Charlotte of Savoy. Upon his succession to the throne of France, the Dauphin abandoned his wife in Burgundy, leaving the young Queen Charlotte dependent on Isabella's aid. After several months of illness, Isabella died of
tuberculosis in Antwerp on 26 September 1465. ==Tomb==