Isatoic anhydride

Hydrolysis gives carbon dioxide and anthranilic acid. Alcoholysis proceeds similarly, affording the ester: :C6H4C2O3NH + ROH → C6H4(CO2R)(NH2) + CO2 Amines also effect ring-opening. Active methylene compounds and carbanions replace oxygen giving hydroxyquinolinone derivatives. Deprotonation followed by alkylation gives the N-substituted derivatives. Sodium azide gives the benzimidazolone via the isocyanate. Isatoic anhydride is used as a blowing agent in the polymer industry, an application that exploits its tendency to release CO2. ==Uses==

Isatoic anhydride has been used as a precursor for the synthesis of methaqualone and related 4-quinazolinone-based pharmaceutical drugs, including: • Tioperidone • Tranilast • Pelanserin • Diproqualone • Antrafenine • SJ-733 • Nicafenine • Molinazone • Cloperidone • SGB 1534 • U-29409 [31785-60-1] ==References==