ISCO or Isco may refer to:Innermost stable circular orbit, the smallest stable orbit around a black hole International Standard Classification of Occupations, an International Labour Organization (ILO) classification structure Information Sharing Customer Outreach, a directorate within the office of the Chief Information Officer (CIO) under the Office of the Director of National Intelligence (ODNI) of the U.S.A. In situ chemical oxidation, a way to remediate organic contamination below the ground surface by direct injection of oxidants Isco, Spanish footballer ISCO, Japan ISCO Optics of Göttingen, Sweden, maker of lenses etc. such as Iscorama ISCO Championship, a golf tournament in the United States