Isehara Station was opened on 1 April 1927, on the Odakyu Odawara Line of the
Odakyu Electric Railway with normal and 6-car limited express services. A new station building was completed in 1967. This was replaced in 2008 by the current station building, with includes a large department store and supermarket operated by the Odakyu Company.
Station numbering was introduced in January 2014 with Isehara being assigned station number OH36. ==Passenger statistics==