The road commences at a roundabout in
Bundaberg North{{cite map |url=https://www.tmr.qld.gov.au/-/media/busind/Heavyvehicles/excessmassdim/District-boundaries-maps/widebaydistrict.pdf?la=en |title=Wide Bay District Map Page 2 Bundaberg Environs |publisher=Department of Transport and Main Roads ©State of Queensland [CC BY 4.0] Childers Road passes to the west of
Bundaberg Airport and through the outer suburbs of
Kensington and
Branyan before reaching the village of
South Bingera. From there to
Apple Tree Creek it passes through a mixture of farm land and forest, with sugar cane and other crops intermixed. Childers Road is in length, making a cumulative distance to the
Bruce Highway at Apple Tree Creek of . From Apple Tree Creek the Isis Highway runs south-east concurrent with the Bruce Highway for to the western outskirts of the town of
Childers, where it turns south on Broadhurst Street as State Route 52. The street name is dropped as the road leaves the town, and the two lane road runs south-west and south through farm land and forest for to
Biggenden. From Biggenden a further generally south-west through similar country leads to the
Burnett Highway at
Ban Ban Springs, making a total cumulative distance of . ==Roads of Strategic Importance upgrade==