Island Creek is a tributary of the Guyandotte River, 18.1 miles (29.1 km) long, in southern West Virginia in the United States. Via the Guyandotte and Ohio rivers, it is part of the watershed of the Mississippi River, draining an area of 105 square miles (270 km2) in a rural area on the unglaciated portion of the Allegheny Plateau, in the Logan Coalfield. Island Creek's entire course and drainage area are in Logan County.