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IsoDMT

isoDMT, also known as N,N-dimethylisotryptamine, is a putatively non-hallucinogenic serotonin 5-HT2A receptor agonist and psychoplastogen of the isotryptamine group. It is the isotryptamine homologue of dimethyltryptamine (DMT), a more well-known serotonergic psychedelic of the tryptamine family, and represents a small structural modification of DMT.

Pharmacology
Pharmacodynamics isoDMT does not produce hallucinogen-like stimulus generalization in animal drug discrimination tests and similarly does not produce the head-twitch response, an animal behavioral proxy of psychedelic-like effects. Its affinities (Ki) for the serotonin 5-HT2 receptors have been reported to be 600–650nM for 5-HT2A and 720nM at 5-HT2C. ==Chemistry==
Chemistry
Analogues Several derivatives of isoDMT have been developed, including the non-hallucinogenic psychoplastogens 5-MeO-isoDMT and zalsupindole (DLX-001; AAZ-A-154; (R)-5-MeO-α-methyl-isoDMT) and the hallucinogen and psychoplastogen 6-MeO-isoDMT. Another analogue of isoDMT is α-methylisotryptamine (isoAMT), the isotryptamine homologue of α-methyltryptamine (AMT). ==History==
History
isoDMT and its derivatives were first described in the scientific literature by 1984. They were subsequently further characterized in 2020. ==See also==
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