Computing •
Incompatible Timesharing System, a computer operating system •
Intelligent tutoring system, an artificial intelligence system used for tutoring •
Internationalization Tag Set, a W3C recommendation for internationalizing XML •
Issue tracking system, computer software that manages product issues
Other science and technology •
Inverse transform sampling, a method for generating random numbers from various probability distribution •
Internal transcribed spacer, a section of DNA located within a set of ribosomal genes •
Interrupted time series, a time series of data known to be affected by interventions ==Vehicular and transport==