• Leslie McGroarty (voiced by
Francesca Marie Smith) is a lively, imaginative, cute and playful young city girl. Leslie liked all of the things such as bicycling, skateboarding, studying karate, insects, eating candy and other masculine things. Leslie has short black hair. She wears circular shaped glasses, a light blue dress with puffed sleeves and a red belt, white socks and black Mary Janes. Leslie had the magical ability to shrink herself to insect size. She is the protagonist of the series. • Itsy Bitsy (voiced by
Frank Welker) is a harmless farm spider. He is Leslie's best friend. Itsy Bitsy is also the protagonist of the
short film. According to an episode, "
Miss Muffet Roughs It", Itsy was a toddler with his parents, living in his farm life. Frank Welker also voices Adrienne's evil pet cat, Langston. • Adrienne Van Leydon (voiced by
Charlotte Rae) is the main antagonist of the series. • The Exterminator (voiced by
Matt Frewer) is the secondary antagonist of the series and Itsy's arch-nemesis. • George (voiced by
Jonathan Taylor Thomas) is Leslie's love interest. ==Episodes==