Cerro Porteno Piris spent three years at
Cerro Porteño, playing a particularly large role in the club's run to the semi-finals of the
2011 Copa Libertadores. His performances in the competition alerted clubs around the world of his ability, and it looked unlikely that he would stay with Cerro Porteño. He eventually signed for Brazilian club
São Paulo FC for a fee of alleged €2 million. São Paulo signed Piris on a two-year loan deal on 19 July 2011 from a proxy club
Deportivo Maldonado.
São Paulo Piris joined up with his new teammates after the
2011 Copa América after São Paulo announced his signing on Thursday 15 July.
Roma On 1 August 2012, Piris was loaned to Italian side
Roma for a fee of €700,000, with the option of purchasing his rights at the end of the 2012–13 season for €4 million. He was virtually ever-present in the side under
Zdeněk Zeman but, following the arrival of
Aurelio Andreazzoli, he found playing time more difficult to come by, having to compete with
Vasilis Torosidis.
Sporting Lisbon Piris signed with
Sporting on loan for the 2013–14 season.
Udinese Piris returned to Italian Serie A for
Udinese in August 2014. According to
La Gazzetta dello Sport it was a loan,
Monterrey ==International career==