1999–2005: Early roles and breakthrough After several dubbing stints, Calzado made a guest appearance in the drama series
Click. In 2002, she played a supporting role in her first soap opera
Kung Mawawala Ka. Her performance landed Calzado her first lead role in the romantic drama
Te Amo, Maging Sino Ka Man opposite Argentine actor
Segundo Cernadas. She also appeared in four films in 2004. She made her first film appearance in
Olivia Lamasan's romantic drama
Milan. She next played supporting roles in the psychological drama
Sabel and the romantic comedy
Annie B. Her final role of the year was in the supernatural horror film
Sigaw. Her performance was lauded by the critics, earning Calzado her first
Gawad Urian Award for Beat Supporting Actress, in addition to a nomination at the
Metro Manila Film Festival in the same category. The year 2005 marked a high point in Calzado's career. She took hosting stints through the morning show
3R (Respect, Relax, Respond) with
Chynna Ortaleza and the public affairs show
At Your Service: Star Power where she served as the main host. The same year, she starred in her breakthrough role Amihan in the fantasy drama
Encantadia. The series was a success, garnering an all-time high rating of 51.7%, becoming
GMA Network's third highest-rating TV show of all time. For her performance, Calzado was named Best Actress at the
USTv Student's Choice Awards. Following its success, Calzado reprised her role as Amihan in
Etheria: Ang Ikalimang Kaharian ng Encantadia for the second installment of the
Encantadia franchise. She also appeared in three films that year. She played supporting roles in the comedies
Pinoy/Blonde and
Ispiritista: Itay, May Moomoo. For her final film of the year, Calzado reprised her role as Amihan in the fantasy
Mulawin: The Movie, an entry for the
31st Metro Manila Film Festival.
2006–2008: Moments of Love, Impostora, Desperadas and One True Love In 2006, Calzado appeared in three film productions. She played Divina Buenacer in
Mark A. Reyes' romantic drama
Moments of Love opposite
Dingdong Dantes. A surprise hit at the box office, it was followed up by another romantic drama
Eternity with Dantes which also stars
Jennylyn Mercado and
Mark Herras. She next appeared as a vampire-like creature disguised as a nanny in the eighth installment of the horror
Shake, Rattle and Roll 8. The film earned ₱57 million at the box-office throughout its run at the
Metro Manila Film Festival, becoming the third highest-grossing film of the festival. That year, Calzado also starred in two television projects. For the last time, Calzado reprised her role as Amihan in
Encantadia: Pag-Ibig Hanggang Wakas, the third installment of the franchise. The series was still a success, becoming the third most watched program with an average rating of 32.2%, based on
Mega Manila TV household between January and February 2006. She next played a supporting role in the fantasy series
Atlantika. In 2007, Calzado made appearances in the anthology
Magpakailanman. She starred alongside
Sunshine Dizon in
Maryo J. de los Reyes' drama
Impostora. The series was well received by the audience, garnering 37.6% rating in its finale based on
AGB Neilsen's overnight ratings among
Mega Manila households, beating
Marian Rivera's
Marimar. The same year, Calzado also had five film releases. She played a maternal role in the psychological thriller
Blackout. She next played the lead in the indie film
Mona: Singapore Escort. Calzado also starred in the supernatural horror
Ouija with
Judy Ann Santos,
Jolina Magdangal and
Rhian Ramos. The film was a success at the box office, grossing ₱60 million within its first week. Calzado had two more major releases by the end of the year. She starred in the romantic drama
Batanes: Sa Dulo ng Walang Hanggan with Taiwanese actor
Ken Chu. Her final film appearance was in the comedy
Desperadas. The film performed moderately at the box-office with ₱35.5 million earnings, becoming the fourth highest-grossing entry at the
Metro Manila Film Festival. Calzado appeared in four television projects in 2008. She played a supporting role as
Robin Padilla's leading lady in the action fantasy
Joaquin Bordado. For her portrayal, Calzado became a semi-finalist in consideration for a nomination at the
International Emmy Awards. She next top billed the suspense thriller series
E.S.P. where she played as an investigative journalist. She also starred in a number of episodes in the anthology
Obra and made a guest appearance in the series
LaLola. That year, Calzado also appeared in four films. She starred alongside
Marian Rivera and
Dingdong Dantes in the romance mystery
One True Love. She next played a supporting role in the horror comedy
Scaregivers. She reprised her role as Stephanie in the sequel
Desperadas 2. The film performed moderately at the box-office throughout its run at the
Metro Manila Film Festival, earning over ₱40 million. She also reprised her role as the victimized wife in the supernatural horror
The Echo, an American remake of
Yam Laranas'
Sigaw.
2009–2011: All About Eve, Dukot and hosting stints The following year, Calzado appeared in more than ten projects in television and film. After appearing in the anthologies
SRO Cinemaserye and
Dear Friend, she reunited with
Sunshine Dizon in the drama
All About Eve. According to
AGB Neilsen, the series garnered 31.8% ratings, becoming the No. 1 most watched show on television occasionally throughout its run. She next topbilled the afternoon drama
Kaya Kong Abutin ang Langit with
Wendell Ramos. She then appeared as one of the councils in the reality talent competition
Starstruck V. Calzado made a cameo appearance in the horror drama
Sundo and next played a supporting role in the drama comedy
Fuschia. Calzado also starred in the political thriller
Bente with
Richard Gomez and
Snooky Serna. She next played supporting roles in the comedy
Yaya and Angelina: The Spoiled Brat Movie and fantasy
Ang Panday. Her final film project of that year was in the political drama
Dukot with
Allen Dizon. Calzado's performance was acclaimed by the critics, earning her Best Actress nominations at the
FAMAS,
Gawad Urian and
Star Awards for Movies, in addition to winning Best Performance by an Actress in a Leading Role at the
Golden Screen Awards. In 2010, Calzado ventured into more hosting gigs. She was the main host in the cooking show
Healthy Cravings, co-hosted the musical variety show
Party Pilipinas and the lifestyle show
The Sweet Life. After playing Teresa in the anthology
Claudine, she played Maria Makiling in the drama fantasy
Panday Kids and starred in
Joel Lamangan's drama
Beauty Queen. The series was a success, reigning over
Mega Manila in TV ratings. That year, Calzado also starred in three films. She was cast as one of the leads in
Jose Javier Reyes'
Working Girls. She next played the Black Lady in
Topel Lee's supernatural horror
White House alongside
Gabby Concepcion,
Lovi Poe and
Maricar Reyes. Calzado' s final film appearance in 2010 was a supporting in the drama
HIV: Si Heidi, Si Ivy at Si V which stars
Jake Cuenca. The
Department of Health (DOH) invested in the film to help "boost the agency’s anti-HIV/AIDS campaign." In 2011, Calzado replaced
Regine Velasquez as the lead in the latter part of the romantic comedy
I Heart You, Pare!, which also stars
Dingdong Dantes. The series was a success, receiving an average of 22.9% ratings in Mega Manila for its finale episode. She next starred opposite
Cesar Montano in her first situational comedy
Andres de Saya. Calzado's last projects with
GMA Network were hosting stints in
Eat Bulaga! and
Showbiz Exclusives.
2012–2016: Transfer to ABS-CBN, Starting Over Again, and stage debut After nearly ten years with
GMA Network, Calzado signed a three-year exclusive contract with
ABS-CBN. Her first acting stint under her new home studio was in an episode of
Maalaala Mo Kaya where she starred alongside
Zanjoe Marudo. She became an occasional performer in the musical variety show
ASAP and starred in
Wenn V. Deramas' romantic drama the ''
Kahit Puso'y Masugatan with Gabby Concepcion, Jake Cuenca and Andi Eigenmann. In 2013, Calzado made guest appearances in the sitcom Toda Max and melodrama Muling Buksan ang Puso''. That year, she played a supporting role in
Jun Lana's historical drama ''
Barber's Tales. The following year, she hosted the second season of The Biggest Loser Pinoy Edition: Doubles. The reality show was a success with 10% rating on its pilot episode, higher than its timeslot rival A 100 Year Legacy
with only 8.2%. She next starred in the family drama Hawak Kamay'' with
Piolo Pascual. According to
Kantar Media, the series registered 33.5% nationwide rating for its finale episode, becoming the most watched program in the Philippines. In 2014, Calzado appeared in two productions under
Star Cinema and one in
Regal Entertainment. Her first release was Olivia Lamasan's
Starting Over Again, a romantic drama co-starring
Piolo Pascual and
Toni Gonzaga. The film became Calzado's biggest commercial success to date, earning ₱579 million at the box office. For the film, she was named Film Actress of the Year at the
46th Box Office Entertainment Awards. She next appeared in the romantic comedy
Somebody to Love with an ensemble cast. She then starred alongside
Jodi Sta. Maria and
Zanjoe Marudo in supernatural horror
Maria Leonora Teresa. The film performed moderately commercially, earning ₱72.7 million at the box office. Calzado appeared in two film projects in 2015. She starred in
Chito S. Roño's romantic drama
Etiquette for Mistresses, co-starring
Kris Aquino,
Claudine Barretto,
Kim Chiu and Cheena Crab. Writing for
Philippine Entertainment Portal, Maridol Ranoa-Bismark described Calzado's performance "Outstanding" saying: "Iza, even with the experienced actress Claudine, leaves no one in doubt that she is an important actress." Rito Asilo of
Entertainment Inquirer also praised her portrayal saying: "she proves that a fine performance isn’t compromised by the quantity of scenes she appears in." For the film, Calzado earned a nomination for Movie Actress of the Year at the
32nd PMPC Star Awards for Movies. That year, she also made a cameo appearance as Colonel Olivia Buenaventura in the action drama
Ang Probinsyano. Calzado was handpicked by National Artist
Benedicto Cabrera to be the subject in her stage debut
Sabel, which was the first original Filipino theater production to be staged at the
Solaire Theater. Calzado took a break from television and appeared in four productions in 2016. She played a supporting role in
Mark Dacascos' international action film
Showdown in Manila. The Cine Filipino Film Festival saw the release of
Buhay Habangbuhay. Calzado next appeared in the romantic comedy
My Candidate, co-starring
Shaina Magdayao and
Derek Ramsay. She also made a cameo appearance in the comedy drama
Die Beautiful. Later in 2016, Calzado served as one of the jury members at the
4th Hanoi International Film Festival in Vietnam.
2017–present: Established actress Calzado made her television comeback in 2017 through the family drama
A Love to Last, co-starring
Bea Alonzo and
Ian Veneracion. The series registered high viewership, garnering 27.8% nationwide ratings. That year, Calzado also made a cameo in
Cathy Garcia-Sampana's family drama
Seven Sundays and starred in two films released on the first quarter of the year. She played a maternal character in
Dan Villegas' indie supernatural horror
Ilawod. It was followed up by
Jerrold Tarog's psychological thriller
Bliss. The film competed at the
Osaka Asian Film Festival where Calzado won the Yakushi Pearl for Best Performance, in addition to winning Movie Actress of the Year at the
PMPC Star Awards for Movies and Film Actress of the Year at the
Box Office Entertainment Awards. In 2018, Calzado starred in the independent film
Distance. The film competed at the
Tokyo International Film Festival. For her portrayal, she received a nomination for Best Actress at the
Cinemalaya Philippine Independent Film Festival and
PMPC Star Awards for Movies. Calzado also appeared in the romantic drama
Ngayon at Kailanman. For ger performance, Calzado received a nomination for Best Drama Supporting Actress at the
PMPC Star Awards for Television. Calzado starred in three productions in 2019. She reunited with
Sunshine Dizon,
Karylle and
Diana Zubiri in
Mark A. Reyes'
Mystified, a fantasy film which premiered on the streaming service
iflix. The film received four nominations at the
Asian Television Awards, winning in the category Best Single Drama or Telemovie, in addition to a nomination for an
Asian Academy Creative Awards. She next starred in the crime drama
Pandanggo sa Hukay, an entry to the
Cinemalaya Philippine Independent Film Festival. It was followed by
Alvin Yapan's historical drama
Culion, co-starring
Jasmine Curtis-Smith and
Meryll Soriano. For the two films, Calzado received a Jury Award for Best Performance at the Gawad Tanglaw Award. In 2020, Calzado starred as the main antagonist in FM Reyes'
Ang sa Iyo ay Akin, co-starring
Jodi Sta. Maria,
Sam Milby and
Maricel Soriano. The revenge drama was the first
ABS-CBN series to be released following the denial of the broadcast franchise of the network by a congressional panel. Upon its release on the streaming service
Netflix, the series became the No. 1 most watched show on Netflix Philippines. For her performance, Calzado won Outstanding TV Actress of the Year at the Laguna Excellence Awards, Best Performance by an Actress at the 5th GEMS Hiyas ng Sining, and Best Actress at the Gawad Tanglaw Awards, in addition to Best Drama Actress nomination at the
PMPC Star Awards for Television. The same year, Calzado next appeared in two web series. She starred opposite
Jameson Blake in the romance
Loving Emily. which premiered on
iWantTFC. In 2021, she starred in an episode of
Maalaala Mo Kaya with
Sharmaine Buencamino. The following year, Calzado made a special participation in the action drama ''
Mars Ravelo's Darna where she played the first Darna. In 2023, she made her film comeback in the sixteenth installment of the horror anthology Shake, Rattle & Roll Extreme''. It premiered on November 30, 2023, after it failed to make the cut of the
Metro Manila Film Festival.. Meanwhile, during the ABS‑CBN Christmas Special 2025, Iza Calzado confirmed and said that she no longer has an exclusive contract with the Kapamilya network and work as a freelance actress. Her contract with ABS‑CBN expired in 2022, during the network shutdown. She affirmed that she will remain ‘Kapamilya’ even without a contract.” ==Philanthropy and advocacy==