After the cancellation of the previous edition, NOS Alive '21 was scheduled to take place on the 7th, 8th, 9th and 10 July 2021, with all previous bought tickets valid for the new dates or refunded. In early May 2021, Everything is New's CEO, Álvaro Covões, expressed his doubts regarding the execution of the festival that year due to the
COVID-19 pandemic. The edition was eventually cancelled on 20 May 2021, with all previously bought tickets valid for NOS Alive '22. Before the cancellation, the planned lineup was the following: == NOS Alive '22 ==