Pre-draft On January 26, 2013, Doyle played in the
2013 Senior Bowl as part of the
Oakland Raiders' head coach
Dennis Allen's North team that lost 21–16 to
Detroit Lions' head coach
Jim Schwartz' South team. Doyle did not receive an invitation to participate at the
NFL Scouting Combine. On February 21, he held a private pro day and had scouts and team representatives from 20 NFL teams attend. He ran the majority of combine and positional drills, but elected to skip the bench press. Doyle was mentored by former Indianapolis Colts' tight end
Ken Dilger in preparation for his pro day. At the conclusion of the pre-draft process, Doyle was projected to be a seventh round pick or priority undrafted free agent by NFL draft experts and scouts. He was ranked as the 20th best tight end prospect in the draft by DraftScout.com.
Tennessee Titans On May 1, 2013, the
Tennessee Titans signed Doyle to a three-year, $1.49 million contract as an
undrafted free agent after going undrafted in the
2013 NFL draft. Throughout training camp, he competed to be a backup tight end against
Taylor Thompson,
Brandon Barden, and
Martell Webb. On August 31, the Titans waived Doyle as part as their final roster cuts, but planned to re-sign him to their practice squad after clearing waivers.
Indianapolis Colts 2013 On September 1, 2013, the
Indianapolis Colts claimed Doyle off of waivers and added him to their active roster. Head coach
Chuck Pagano named Doyle the fourth tight end on the Colts' depth chart to begin the regular season, behind
Dwayne Allen,
Coby Fleener, and
Dominique Jones. Doyle made his professional regular season debut during the Week 2 24–20 loss to the
Miami Dolphins after Dwayne Allen was placed on injured reserve due to a hip injury he sustained in the season-opener. During a Week 7 39–33 victory over the
Denver Broncos, Doyle caught his first career reception on a seven-yard pass from quarterback
Andrew Luck before being tackled by
Danny Trevathan during the third quarter. The following week, Doyle was promoted to being the primary backup on the depth chart behind Coby Fleener and earned his first career start during a 27–24 road victory over the
Houston Texans after the Colts released Dominique Jones. Doyle finished his rookie year with five receptions for 19 yards in 15 games and four starts. The Colts finished the 2013 season atop the
AFC South with an 11–5 record. On January 4, 2014, Doyle appeared in his first career playoff game as the Colts narrowly defeated the
Kansas City Chiefs by a score of 45–44 during the AFC
Wild Card Round. On January 11, 2014, Doyle started in his first career playoff game and had a seven-yard reception during a 43–22 road loss to the
New England Patriots in the AFC
Divisional Round.
2014 During training camp, Doyle competed for a roster spot as a backup tight end against
Weslye Saunders and
Erik Swoope. Head coach Chuck Pagano named Doyle the third tight end on the Colts' depth chart to begin the regular season, behind Dwayne Allen and Coby Fleener. During a Week 2 30–27 loss to the
Philadelphia Eagles, Doyle scored his first NFL touchdown on a two-yard touchdown pass by quarterback
Andrew Luck in the second quarter, which also marked Luck's 50th career touchdown pass. In the regular-season finale against the
Tennessee Titans, Doyle caught a season-high four receptions for 21 yards and a touchdown during the 27–10 road victory. Doyle finished his second professional season with 18 receptions for 118 yards and two touchdowns in 16 games and one start. Doyle played 399 offensive snaps (34.5%) and was mainly used as a blocker in
Pep Hamilton's offense. The Colts finished the 2014 atop the AFC South with an 11–5 record and reached the
AFC Championship Game, where they were defeated on the road 45–7 by the Patriots.
2015 Head coach Chuck Pagano named Doyle the third tight end on the depth chart to begin the regular season, behind
Dwayne Allen and
Coby Fleener. During Week 3 against the Titans, Doyle recorded a season-high three receptions for 32 yards in the narrow 35–33 victory. During a Week 9 27–24 victory over the Broncos, he had two receptions for 18 yards and a touchdown in the 27–24 victory. He recorded a three-yard touchdown reception that also marked quarterback Andrew Luck's 100th career touchdown pass. On November 23, 2015, the Colts fired offensive coordinator Pep Hamilton and promoted associate head coach Rob Chudzinski to offensive coordinator for the rest of the season. Doyle finished the 2015 season with 12 receptions for 72 yards and a touchdown in 16 games and two starts.
2016 On March 3, 2016, the Colts extended a
qualifying offer to Doyle as a restricted free agent. On April 24, he accepted his one-year, $1.67 million
restricted free agent tender after not getting any control offers from any other team. Doyle entered training camp slated as the secondary starting tight end on the depth chart after
Coby Fleener departed during free agency. Head coach Chuck Pagano officially named Doyle and
Dwayne Allen the starting tight ends to begin the regular season. Doyle started in the season-opening 39–35 loss to the
Detroit Lions and caught three passes for 35 yards and two touchdowns, marking his first multi-touchdown game of his career. During a Week 7 34–26 road victory over the Titans, Doyle had a season-high nine receptions for 78 yards and a touchdown. Doyle finished the 2016 season with 59 receptions for 584 yards and five touchdowns in 16 games and 14 starts.
2017 On March 7, 2017, the Colts signed Doyle to a three-year, $18.9 million contract with $7.5 million guaranteed. Doyle entered training camp slated as the No. 1 starting tight end on the depth chart after Dwayne Allen was traded to the
New England Patriots. Head coach Chuck Pagano named Doyle the starting tight end to begin the regular season. During Week 4 against the
Seattle Seahawks, Doyle caught five passes for 27 yards before leaving the eventual 46–18 road loss in the third quarter with a
concussion. He was inactive for next game against the
San Francisco 49ers due to neck soreness. During a narrow Week 8 24–23 road loss to the
Cincinnati Bengals, Doyle caught a career-high 12 receptions for 121 yards and a touchdown. On December 31, 2017, the Colts fired head coach Chuck Pagano and his coaching staff after they finished the 2017 season with a 4–12 record. Doyle finished the 2017 season with a career-high 80 receptions for 690 yards and four touchdowns in 15 games and starts. On January 21, 2018, it was announced that he was selected to play in the
2018 Pro Bowl as a replacement for Patriots tight end
Rob Gronkowski, who was set to appear in
Super Bowl LII. Doyle became the first Western Kentucky alumni to be selected to the Pro Bowl in school history.
2018 In 2018, Doyle missed five games with a hip injury before being hospitalized following the Week 12 game with a kidney injury. He was placed on injured reserve on November 26, 2018. Doyle finished the 2018 season with 26 receptions for 245 yards and two touchdowns in six games and starts.
2019 On December 6, 2019, Doyle signed a three-year, $21 million contract extension with the Colts through the 2022 season. In 2019, Doyle started all 16 games and finished with 43 receptions for 448 yards and four touchdowns. After the season, he was named to the
2020 Pro Bowl as a replacement for
Travis Kelce, who was appearing in
Super Bowl LIV.
2020 In the 2020 season, Doyle had 23 receptions for 251 yards and three touchdowns in 14 games and 12 starts. During the
Wild Card Round against the
Buffalo Bills, Doyle had seven receptions for 70 yards and a touchdown to go along with a two-point conversion in the 27–24 road loss.
2021 During Week 5 against the
Baltimore Ravens, Doyle drew a personal foul penalty against
Tavon Young in the final minute of the game when he pushed Young's head into the ground after a play, then fell when Young pushed him back. This penalty allowed the Colts to turn a 3rd and 18 into an opportunity for a 47-yard field goal to win the game. However, Colts kicker
Rodrigo Blankenship would miss the kick and the Colts would go on to lose on the road by a score of 33–27 in overtime. Doyle finished the 2021 season with 29 receptions for 302 yards and three touchdowns in 17 games and 14 starts.
Retirement On March 7, 2022, Doyle announced his retirement from the NFL. ==Career statistics==