Following his studies in the United Kingdom, Blukoo-Allotey returned to Ghana where he registered as a medical personnel on 12 May 1961. While working as a lecturer at the University of Ghana Medical School, he was appointed chairman of the State Pharmaceutical Corporation. In 1968, the corporation became a division of the
Ghana Industrial Holdings Corporation (GIHOC) and he acted as general manager of the division. In 1970, he was sent to
Europe by the Ghana Industrial Holdings Corporation on a special leave from the
University of Ghana. On his return, he was appointed general manager of the State Pharmaceutical division of GIHOC and run a factory. In 1973, he was a member of the advisory council of the then newly established
Centre for Scientific Research into Plant Medicine in Mampong, Akwapim. In 1994, he became council chairman of the
Centre for Scientific Research into Plant Medicine, after
Charles Easmon, and held this role until 2005. In 1982, he was appointed member of the then newly formed
PNDC government by the then chairman of the PNDC,
Jerry John Rawlings. He however declined the appointment, and his request for exemption from the national government was accepted by the then chairman Rawlings. ==Honours==