Barron was selected by the
Denver Broncos in the first round (20th overall) of the
2025 NFL draft. Upon being drafted, Barron requested to speak to the Broncos' draft room to personally thank every person there for choosing him. Barron signed his four-year rookie contract, worth $18.07 million fully guaranteed, on July 15, 2025. Initially wearing #12, Barron switched to #23 after the Broncos cut
Audric Estimé prior to the beginning of the season. He had worn the number for his first four years in college to honor Tardrick Fowler Jr., a deceased family friend. Barron made his NFL debut in Week 1 against the
Tennessee Titans. In the game, Barron recorded one tackle and one fumble recovery that sealed the win for the Broncos 20–12. In Week 8 against the
Dallas Cowboys, he recorded his first NFL career interception. ==Career statistics==