In the early nineteenth century, the prevalence of
yellow fever in the Caribbean "led to serious health problems" and alarmed the United States Navy as numerous deaths and sickness curtailed naval operations and destroyed morale. A tragic example occurred in May 1822 when the frigate
USS Macedonian left Boston and became part of Commodore James Biddle's
West Indies Squadron. Secretary of the Navy
Smith Thompson had assigned the squadron to guard United States merchant shipping and suppress piracy. During their deployment seventy six of the Macedonian officers and men died. Seventy four of these deaths were attributed to
yellow fever. Biddle reported another fifty two of his crew were on sick-list. In his report to the Secretary of the Navy, Biddle and Surgeon's Mate Dr. Charles Chase state the cause as "fever". As a consequence of this loss Biddle noted his squadron was forced to return to
Norfolk Navy Yard early. The
Macedonian crew upon arrival were provided medical care and quarantined at
Craney Island. Biddle upset at the loss of his crew wrote Smith Thompson " how deeply my feelings have been afflicted at the disturbing mortality & sickness and …. I hope you will order an investigation into the cause of the sickness on board." Biddle told Thompson the
Macedonian had been improperly fitted out in Boston and while there, the frigate's hold was never properly cleaned and that the filth and debris he discovered in the hold had led to the fever. Biddle consequently brought charges against Commodore Isaac Hull then in command at the Boston Naval Yard. Medical testimony during a court of inquiry however supported the conclusion that a drastic change in temperatures, dampness and tropical climate were the proximate cause of the fever, and "Much to Biddle's chagrin the court of inquiry found Hull not guilty." ==Expeditions to Asia==