In 1859, Hepburn went to Japan as a medical missionary with the
American Presbyterian Mission. In the spring of 1862, Hepburn and his family relocated to the house and compound at Kyoryūchi No. 39, in the heart of the foreigners residential district in the treaty port of Yokohama. There, in addition to his clinic, he and his wife Clara founded the Hepburn School, which eventually developed into
Meiji Gakuin University. Hepburn's Japanese pupils included
Furuya Sakuzaemon,
Takahashi Korekiyo,
Okakura Kakuzō, and
Numa Morikazu. For his medical contributions to the city of Yokohama, Hepburn Hall was named in his honor on the campus of
Yokohama City University School of Medicine. In May 1867, with the collaboration of his long-time assistant Kishida Ginkō, Hepburn published a Japanese–English dictionary which rapidly became the standard reference work for prospective students of Japanese. In the dictionary's third edition, published in 1886, Hepburn adopted a new system for
romanization of the Japanese language developed by the
Society for the Romanization of the Japanese Alphabet (
Rōmajikai). This system is widely known as the
Hepburn romanization because Hepburn's dictionary popularized it. Hepburn also contributed to the translation of the Bible into Japanese. ==Later years==