James Derham was born into slavery in Philadelphia in 1762. As a child, Derham was transferred to John Kearsley Jr., under whom Derham studied medicine. From Kearsley, Derham learned about compound medicine focusing on curing throat illnesses, By 1789, his practice is reported to have made about $3,000 (approximately $ in ) annually. In 1788, Derham and
Benjamin Rush met each other in Philadelphia, and corresponded with one another for twelve years. Derham's final letter to Rush in 1802 is the last record of his existence. It is believed that after the Spanish authorities restricted Derham to treating throat diseases in 1801, Derham left his practice in New Orleans. == Derham in literature ==