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James Fleming (author) (1944–2024), author of the "Charlie Doig" thrillers •
James Fleming (British Army officer) (1682–1751), British major-general •
James Fleming (lawyer) (1831–1914), Scottish lawyer •
James Fleming (priest) (1830–1908), clergyman of the Church of England •
James E. Fleming (born 1954), American lawyer and professor of law •
James Henry Fleming (1872–1940), Canadian ornithologist •
James P. Fleming (born 1943), American military pilot who received the Medal of Honor •
James Rodger Fleming (born 1949), historian of science and technology •
James Simpson Fleming (1828–1899), Scottish lawyer and banker •
James W. Fleming (1867–1928), American businessman, banker and politician