In his missionary pursuits, he made over fourteen expeditions to the west and southwest. In 1800, he established the first protestant mission in Natchez, Mississippi. In 1801, he published a book on articles that he had written on this area of Mississippi,
A brief history of the Mississippi Territory, to which is prefixed a summary view of the country between the settlements on Cumberland River & the territory. He also wrote a book,
A narrative of a most extraordinary work of religion in North Carolina. When he was a young minister, he founded Clio's Nursery/Academy about ten miles north of
Statesville, North Carolina in about 1778 and the Ebenezer Academy near his home north of Statesville. He may have also published a grammar for use by his students. He was an active supporter of his alma mater,
Princeton University, and the
University of North Carolina. Both schools conferred an honorary doctor of divinity on him. ==Death==