In 1837, Laughlin was married to Ann McCully Irwin (1813–1891), a daughter of Boyle Irwin and Eliza ( McCully) Irwin. • Irwin Boyle Laughlin (1840–1871), who married Mary Wood Bissell, a daughter of John Bissell, in 1870. • George McCully Laughlin (1842–1908), who married Isabel Bowman McKennan, a daughter of
Judge William McKennan of the
Third Circuit Court of Appeals, in 1865. • Elizabeth "Eliza" Irwin Laughlin (1844–1929), who married
Duncan Clinch Phillips, a Pittsburgh window glass millionaire, in 1883. • James Laughlin (1847–1919), who married Sidney Ford Page, the youngest child of John Harding Page. American poet and literary book publisher
James Laughlin IV is descended from Laughlin. Laughlin died at his home in Pittsburgh on December 18, 1882. ==References==