•
James Riley (captain) (1777–1840), American merchant ship captain •
James McIlvaine Riley (1849–1911), American co-founder of the Sigma Nu fraternity •
James Whitcomb Riley (1849–1916), American writer and poet •
Doc Middleton (James M. Riley, 1851–1913), American outlaw and horse thief •
James Riley (gunman) (1853–?), American gunfighter •
James Frederic Riley (1912–1985), British physician, radiologist and cancer specialist •
James Riley (POW) (born c. 1972), American soldier captured in Iraq, see
American POWs in the 2003 invasion of Iraq •
James Riley (writer) (born c. 1977), American novelist •
James J. Riley, American mechanical engineer ==Other uses==