In 1791 the
Delaware General Assembly appointed Sykes to help manage a lottery to raise one thousand pounds to defray expenses incurred in constructing a new state house. After serving as clerk for the State House in 1796, he was elected to the State Senate in 1793. He served one term for the 1794, 1795, and 1796 sessions. Returning a year later, he served six more terms from the 1798 session through the 1812 session. He was Speaker in 1801, and then in every session from 1804 through 1812. He was also the Democratic-Republican nominee in all three of Delaware's U.S. Senate elections in 1798 and 1799. On February 20, 1801, Governor
Richard Bassett resigned following his appointment as
U.S. Circuit Court Judge by
U.S. President John Adams. As the Speaker of the State Senate, Sykes was next in line of succession and took office as governor. He chose not to run for election in his right, and returned to the State Senate on January 19, 1802. In the meantime, Sykes had become one of the state's most renowned surgeons. From his office at 45 The Green in Dover, he specialized in treating
gallstones and
yellow fever. In 1814 he moved his practice to
New York City for six years, but then returned to the Dover practice with his son, James. In 1822 he became President of the Delaware Medical Society. ==Death and legacy==