In Wayne's first season with the Panthers in 2019 he caught 18 passes for 261 yards and one touchdown. In Wayne's second season he recorded 21 receptions for 326 yards and a touchdown. However, in Wayne's third season he took a huge step up making 47 catches for 658 yards and six touchdowns. In Wayne's final season in 2022 he had a breakout season. On October 29 Wayne had a great performance against
North Carolina bringing in seven receptions and 160 yards. In Pittsburgh's season finale Wayne had the best game of his career after catching 11 passes for 199 yards and three touchdowns all career highs in a win against
Miami. For his performance, he was named the ACC wide receiver of the week. On the season Wayne brought in 60 receptions for 1,063 yards and five touchdowns. For his performance on the year he was named Second Team All-ACC. He was also named one of the five finalists for the Jon Cornish trophy which is awarded to the best Canadian player. After the conclusion of the 2022 season, Wayne declared for the
NFL draft. Wayne was also invited to play in the
2023 Hula Bowl. ==Professional career==