Drynan started out in guest roles in numerous Australian television series including
Hunter,
Skippy,
Riptide,
The Rovers,
Division 4,
The Link Men,
Delta,
Matlock Police,
Spyforce,
Boney,
Homicide and
Ryan. She also had early roles in 1966 comedy film
They’re a Weird Mob, and 1967 television play
The Schoolmistress. She then starred in high school-based soap opera
Class of ‘74 as English teacher Mary Dunstan, and 1976 political-themed film
Don’s Party (based on the play of the same name by
David Williamson) as Kath Henderson. Further guest roles followed in
Bluey,
The Young Doctors and
Chopper Squad, before she secured the part of solicitor, Angela Jeffries in cult classic television drama
Prisoner in 1979, endearing her to international viewers. Further guest roles followed, in series such as
Cop Shop,
A Country Practice,
The Flying Doctors, ''
Rafferty's Rules, The Girl from Tomorrow and G.P. before she landed her best-known role as the ill-fated Betty Heslop, mother of the title character in 1994 hit film Muriel's Wedding'', alongside
Toni Collette,
Rachel Griffiths and
Bill Hunter. She starred in numerous other films including the 1999 romantic comedy
Paperback Hero (as Suzie, opposite
Hugh Jackman), drama film
A Kind of Hush (as Beryl) and comedy/drama
Soft Fruit (in the lead role of Patsy), before appearing as Vanessa in 6 episodes of comedy series
Dossa and Joe (2002) and Leanne in 4 episodes of
The Cooks (2003–2005). Drynan has been nominated three times for
Australian Film Institute Awards – Best Supporting Actress in 1977 for
Don’s Party, Best Supporting Actress in 1994 for ''
Muriel's Wedding and Best Actress in 1999 for Soft Fruit''. ==Personal life==