From 1737 to 1745 Wentworth was Colonel of what would soon become the
24th Regiment of Foot. He became commander of the land troops in the amphibious expedition against
Cartagena de Indias following the deaths of the original commander, Lord Cathcart, and his second-in-command, General Spotswood, during the
War of Jenkins' Ear. He and his troops arrived there in 1741 in a fleet led by Rear-Admiral Sir
Chaloner Ogle to reinforce Vice-admiral
Edward Vernon, but the British forces still failed to take the town and the land forces suffered catastrophic losses of nearly ninety percent over the course of two years' campaigning, mostly from disease. Wentworth was returned as Member of Parliament for
Whitchurch at a by-election in 1743. He voted with the Administration in 1744, and then served in Flanders. In 1745, he was with
George Wade, during the
Jacobite rising of 1745. He did not vote on the Hanoverians in 1746. ==Death==