In 1888, Harrington began his professional career in the
Central Interstate League. That season, he played for the
Danville Browns, the Davenport club, and the Decatur club. Harrington continued to play in the Central Interstate League in 1889 with the
Davenport Hawkeyes/
Monmouth Browns. Harrington made his major league debut on April 30, 1890, with the
Cincinnati Reds. In his first season, he batted .246 with 25 runs, 58 hits, seven doubles, one triple, one home run, 23 RBIs, and four stolen bases in 65 games.
Lee Allen, author of
The Cincinnati Reds, wrote that Harrington and fellow player
Billy Rhines were two top prospects when they joined the Reds, although nearly unknown today. It was also said that Harrington could throw out a
baserunner from his knees. Harrington played his final season with the Reds in 1892. In 22 games, Harrington batted .213 with six runs, 13 hits, one double, and three RBIs. In 1893, Harrington joined the
Louisville Colonels, which would prove to be his final season in professional baseball. With the Colonels, Harrington batted .111 with four runs, four hits, one double, and three RBIs in 10 games. ==Later life==