2013 In
2013, Sene-Lefao joined the
Manly-Warringah Sea Eagles. He made his
NRL debut in the opening round of the season against the
Brisbane Broncos at
Suncorp Stadium, playing off the interchange bench in Manly-Warringah's 22–14 win. Sene-Lefao played his 2nd and last match for the year in round 8. Sene-Lefao spent most of the year playing for the team's
New South Wales Cup team.
2014 Sene-Lefao was selected in Manly's inaugural
2014 NRL Auckland Nines squad. He made his international debut in May for
Samoa in the
test against
Fiji at
Penrith Stadium. Sene-Lefao played off the interchange bench in Samoa's 32–16 win. Soon after, Sene-Lefao re-signed with the Manly-Warringah club on a two-year contract. In round 13 against the
Canterbury-Bankstown Bulldogs at
Brookvale Oval, Sene-Lefao scored his first NRL career try in Manly's 32–10 win. It was the sole try he scored from 25 matches in
2014. At the end of the season, Sene-Lefao was a late selection for Samoa in the
Four Nations after
Suaia Matagi was selected in the
New Zealand national rugby league team squad.
2015 Sene-Lefao was again part of the Manly
Auckland Nines squad in 2015. He scored two tries from his 11 matches in
2015. On 9 October, Sene-Lefao signed a two/year contract with the
Cronulla-Sutherland Sharks, starting from 2016 after he was released from the final year of his contract with Manly.
2016 Sene-Lefao played 6 games for the
Cronulla-Sutherland Sharks in 2016. He was a vital squad member for Cronulla-Sutherland in 2016, filling in for captain Paul Gallen during the semis, and the injured Sam Tagataese towards the end of the season. Although he did not play in Cronulla's 2016 drought breaking premiership win. On 21 October 2016, Sene-Lefao signed a two-year contract with
Castleford Tigers.
2017 Sene-Lefao played in the
2017 Super League Grand Final defeat by the
Leeds Rhinos at
Old Trafford.
2018 In the
2018 Super League season, he made 17 appearances for Castleford as the club finished third on the table but failed to reach the grand final.
2019 Sene-Lefao played 24 games for Castleford as they finished the
Super League XXIV season in 5th place on the table. Castleford reached the second week of the 2019 Super League finals series where they were defeated by Salford 22-0 in the elimination semi-final.
2020 Sene-Lefao made nine appearances for Castleford in the
2020 Super League season. The club finished a disappointing ninth on the table, their lowest finish since 2013.
2021 On 17 July 2021, Sene-Lefao played for Castleford in their
2021 Challenge Cup Final loss against St. Helens.
2022 On 20 December 2021, it was reported that he had signed for
Featherstone Rovers in the
RFL Championship On 28 May, he played for Featherstone in their
2022 RFL 1895 Cup final loss against
Leigh. On 31 October, he signed a two-year deal to join fellow RFL Championship side
Sheffield ahead of the 2023 season. == Statistics ==