In 2004, Klein appears twice in the Season 2 "Wayne Brady Show" episode of ''
Chappelle's Show'': first, in the boardroom to inform Dave of how replaceable he is on the show, and later she along with
Neal Brennan are
gassed by
Chappelle "
in the wings" just before Chappelle confronts
Wayne Brady to take his show back. In 2009, she wrote and co-starred in
Michael and Michael Have Issues on
Comedy Central. She also worked as a writer on
Saturday Night Live during the
2009-2010 season. Klein's
Comedy Central Presents special aired on March 4, 2011. Klein made her first-time appearance as a panelist on
NPR's comedy-news quiz show ''
Wait Wait... Don't Tell Me!'' on June 25, 2011. She was the first female guest host of the program on March 11, 2017. She was an executive producer and writer for
Inside Amy Schumer on Comedy Central since its debut, and won a Primetime Emmy Award for Outstanding Variety Sketch Series in 2015 for her work on the show. She was not a writer on its fifth season. She was also a consulting producer on the series "Transparent" in 2016. Klein released her debut book in July 2016, ''You'll Grow Out of It'', which became a New York Times best seller. Klein's second book, ''I'll Show Myself Out: Essays on Midlife and Motherhood'', was released in April 2022. Klein served as a consulting producer for the Netflix series
animated sitcom Big Mouth between 2017 and 2025, and provided the voice for one of the series' main characters, Jessi Glaser. ==Selected works==