Mothersole's early work in archaeological drawing included drawings of wall paintings from
Saqqara, exhibited by
Flinders Petrie in an exhibition at
University College London in 1904. These followed her work at the 1903–1904 excavation season at Saqqara with
Margaret Murray, where, alongside drawings, Mothersole recorded the season with photographs, some of which were later published in an article "Tomb Copying in Egypt" for the family magazine
Sunday at Home. Her "A Photograph Credited to Mothersole" from this period was taken at
Luxor and is now in the
Petrie Museum. Following her early work in Egypt, in 1910 Mothersole wrote and published her first book, which concerned the
Isles of Scilly, and included 24 of her own colour paintings. She then focused primarily on British archaeology, publishing her self-illustrated book on
Hadrian's Wall in 1922. For this, she drew on both excavation reports and direct contacts with the archaeologists then excavating it, as well making her own observations as she walked the wall's length. Her watercolours of Hadrian's Wall were exhibited 30 October – 11 November 1922 at Walker's Galleries, London. She wrote and illustrated several more books on archaeology and travel. Mothersole, like Henry Holiday, was a campaigner for
women's suffrage. She made a drawing of a fellow campaigner,
Myra Sadd Brown, at a meeting in c.1912, which is held in the archives of the
Women's Library. In 2025, Mothersole was included in an exhibition at
Senate House, London, on "Women of Romano-British Archaeology". ==Select publications==