•
Dean Paul Martin as Dr. Billy Hayes, the leader of the team (who has no superpowers). He is a young research scientist at the Humanidyne Institute who specializes in "human anomalies" and a fast-talking but good-hearted schemer full of boyish enthusiasm who often gets the team into as much trouble as he gets them out of. Although easily distracted whenever an attractive woman walks by, he is honestly interested in getting involved in a serious relationship with Jane Miller even after she showed up pregnant by another man. •
Kevin Peter Hall as Dr. Elvin "El" Lincoln, Billy's colleague and close friend. He has the ability to shrink for minutes at a time from his height of to via hormonal treatments which he activates by pressing a nerve on the back of his neck. A recurring joke after such transformations is that he always has to put on the tiny change of clothes he carries with him for his small size. The character is shy and struggles socially, and despite being so tall, he is a very bad
basketball player. • Mark Thomas Miller as Johnny "Johnny B" Bukowski, a
rock and roll musician who was electrically shocked on stage which resulted in disturbing electrical powers. He continually drains any electrically charged items in his surroundings, forcing him to live in isolation. He wears sunglasses because his eyes glow when he is fully charged. He can throw lightning bolts forcefully and run at superhuman speed, easily outracing in one episode a parody of the
Six Million Dollar Man, but he is vulnerable to water which
short-circuits him and burns his skin. He is a big
Chuck Berry fan. •
Courteney Cox as Gloria Dinallo, a troubled telekinetic teenager with a history of juvenile delinquency and a mother in a mental institution who claims Gloria's father is from outer space. She has a crush on Johnny. Gloria can only use her telekinesis on things that she can see: using a blindfold on her renders her powerless. •
Diane Civita as Miss Nance, the scientists' secretary. Although she usually seems more interested in doing her nails, going on her coffee break, and watching her soap operas, she is actually the one who keeps their department running and is always there at the end of the series to turn off the lights and say goodnight to the rabbits in their cages. •
Jennifer Holmes as Jane Miller, Gloria's
probation officer. Although attracted to Billy, she is often put off by his eccentric behavior. Her character appears only in the earlier episodes, disappearing after the first 7 episodes. (Although Holmes is still in the opening credits through episode 12.) •
Max Wright as Dick Stetmeyer, the uptight director of the Humanidyne Institute. Unlike the other cast members, he isn't actually considered to be one of the Misfits. •
Mickey Jones as Arnold "Beef"/"Ice Man" Beifneiter, who got his power to freeze anything he touches from placing himself in an experimental
cryogenic cold storage unit back in the year of 1937 due to grief caused by the loss of his beloved
Amelia Earhart. The team drives around in an
ice cream truck (
International Metro Mite M-800) because the lumbering and now rather simple-minded Ice Man dies if he gets too warm, so they keep him in the freezer. Beef only appears in the pilot episode due to legal objections from
Marvel Comics, who publish a
similarly named character in
X-Men, but the characters continue to use the ice cream truck. == Episodes ==