Deportivo Pereira Medranda joined the youth program of Colombian club Deportivo Pereira at the age of 12 before eventually earning promotion to the first team at the age of 18. He made two league appearances in
Categoría Primera B during the 2012 season in addition to a
Copa Colombia appearance. In 2013, he made seven league appearances, including four starts, and scored one goal in addition to six Copa Colombia appearances.
Sporting Kansas City In August 2013, Medranda was loaned to
Sporting Kansas City in
Major League Soccer. He made his debut with Sporting in a September 3–0 victory over the
Columbus Crew. Sporting made the transfer permanent ahead of the
2014 season. On November 19, 2019, Medranda was selected by
Nashville SC in the
2019 MLS Expansion Draft.
Nashville SC Medranda made one appearance with Nashville SC.
Seattle Sounders FC On 21 October 2020, Medranda was traded to
Seattle Sounders FC, along with $225,000 in General Allocation Money, for
Handwalla Bwana.
Columbus Crew On 23 December 2022, the Columbus Crew announced they had signed Medranda as a free agent.
Deportivo Cali On August 14, 2024, it was announced that Medranda had signed with the club.
San Antonio FC On 31 January 2025, it was announced that Medranda signed with San Antonio FC. ==Career statistics==