•
Little Joe McLerran (born 1983), American singer, guitarist and recording artist •
Joe Arenas (1925–2020), American retired National Football League player •
Little Joe Blue (1934–1990), American blues singer and guitarist, born Joseph Valery Jr. •
Little Joe Cook (1922–2014), American R&B singer and songwriter •
Joe Dallesandro (born 1948), American actor and counterculture icon, associated with Andy Warhol and Lou Reed •
Joseph DeFede (1934–2012), New York City mob boss turned informant •
Joe Hamilton (basketball) (born 1948), American retired basketball player • "Little Joe" Hupp, a member of the 1960s rock band
The Smoke Ring •
Joe Morgan (1943–2020), American Major League Baseball player •
Joe Pavelski (born 1984), American National Hockey League player •
Joe Presko (1928–2019), American retired Major League Baseball pitcher •
Joe Washington (born 1953), American retired National Football League player •
Joe Weatherly (1922–1964), American stock car racing driver •
Joseph Wentworth, early 20th century American college football player and coach •
Joe Yeager (1875–1937), American Major League Baseball player • Ring name of
Joe Acton (1852–1917), British professional wrestler and world champion •
Little Joe (singer) (born 1940), stage name of American tejano performer José María De León Hernández •
Ranking Joe (born 1959), also known as Little Joe, Jamaican reggae DJ Joseph Jackson •
J.O.E. (1986–2011), Jamaican reggae singer formerly known as 'Lil Joe' or 'Little Joe' •
Little Papa Joe (1935–2018), American blues guitarist and singer •
Little Son Joe (1900–1961), American blues guitarist and composer ==Arts and entertainment==