New York Yankees The
New York Yankees selected Brebbia in the 30th round of the
2011 Major League Baseball draft. He signed and made his professional debut that same season with the
Staten Island Yankees of the
Low-A New York-Penn League, where he was 0–1 with a 0.00 ERA in eight innings. He spent the 2012 season with the
Charleston RiverDogs of the
Single-A South Atlantic League and pitched to a 3–1 record with two saves and a 2.96 ERA in innings over 29 relief appearances.
Sioux Falls Canaries On January 7, 2014, Brebbia signed with the
Sioux Falls Canaries of the
American Association of Independent Professional Baseball. In 34 games with the Canaries, he pitched to a 3–2 record with one save, a 3.31 ERA and 10.5
strikeouts per nine innings pitched (fifth-best in the league).
St. Louis Cardinals On September 21, 2015, Brebbia signed a minor league contract with the
Arizona Diamondbacks and was assigned to the
Double-A Mobile BayBears. In 2016, Brebbia played with both the
Springfield Cardinals of the Double-A
Texas League and
Memphis Redbirds of the
Triple-A Pacific Coast League. He was 5–5 with a 5.03 ERA and 68 strikeouts in 68 innings over 43 games. when the Cardinals promoted him to the major league on May 27, 2017. He made his major league debut against the
Colorado Rockies on May 28 and remained with the Cardinals for the rest of the season. He finished his 2017 rookie campaign with a 2.44 ERA, 11 walks and 51 strikeouts in innings, and a 0.929 WHIP, leading all Major League rookie relievers in ERA and WHIP. On October 29, 2018, Brebbia was selected to the MLB All-Star team at the
2018 MLB Japan All-Star Series, pitching in three games in the series. After first trying
platelet-rich injection (
PRP) treatment for a torn
ulnar collateral ligament in his right elbow Brebbia underwent
Tommy John surgery on June 1, 2020, causing him to miss the 2020 season. In his three seasons with the Cardinals, Brebbia had a 3.14 ERA, and 10.2
K/9.
San Francisco Giants On December 21, 2020, Brebbia signed a one-year, $800,000 contract with the
San Francisco Giants. On February 17, 2021, Brebbia was placed on the 60-day
injured list as he continued to recover from Tommy John surgery. He was activated off of the injured list on June 20, recovering from Tommy John surgery faster than the normal 13–15 month recovery timeframe. In the 2021 regular season for the Giants, Brebbia was 0–1 with a 5.89 ERA. He pitched 18.1 innings over 18 games. For the Triple-A
Sacramento River Cats, he was 3–0 with a 2.93 ERA in 17 games (two starts) in which he pitched innings. In 2022 with the Giants, Brebbia was 6–2 with a 3.18 ERA in 68 innings, as he pitched in a league-leading 76 games (11 starts). On January 13, 2023, Brebbia agreed to a one-year, $2.3 million contract with the Giants, avoiding salary arbitration. He pitched in 29 games for San Francisco, posting a 3.14 ERA with 36 strikeouts, before he was placed on the injured list with a Grade 2
lat strain on June 17. Brebbia was activated from the injured list on September 5.
Chicago White Sox On January 26, 2024, Brebbia signed a one-year, $5.5 million contract with the
Chicago White Sox. In 54 appearances for Chicago, he struggled to an 0–6 record and 6.29 ERA with 58 strikeouts over innings pitched. Brebbia was
designated for assignment by the White Sox on August 27. He was released two days later.
Atlanta Braves On August 31, 2024, Brebbia signed a minor league contract with the
Atlanta Braves. The next day, he was subsequently selected to the team's major league roster. In 5 games for Atlanta, Brebbia posted a 2.70 ERA with 9 strikeouts across innings pitched.
Detroit Tigers On February 12, 2025, Brebbia signed a one-year, $2.75 million contract with the
Detroit Tigers. He started the season with a 1.00 ERA in 8 appearances before being placed on the injured list on April 19 with a right forearm strain. In 19 appearances for Detroit, he struggled to a 7.71 ERA with 20 strikeouts across innings pitched. On June 15, Brebbia was designated for assignment by the Tigers. After clearing waivers on June 19, Brebbia was released by Detroit.
Atlanta Braves (second stint) On June 24, 2025, Brebbia signed a minor league contract with the
Atlanta Braves. In 15 appearances for the Triple-A
Gwinnett Stripers, he totaled a 1.89 ERA and 21 strikeouts across 19 innings pitched. On August 29, the Braves selected Brebbia's contract, adding him to their active roster. In three appearances for Atlanta, he accumulated a 7.71 ERA with six strikeouts across innings pitched. On September 8, Brebbia was designated for assignment by the Braves. He elected free agency after clearing waivers on September 10.
Boston Red Sox On September 13, 2025, Brebbia signed a minor league contract with the
Boston Red Sox. He did not appear for the organization and elected free agency following the season on November 6.
Minnesota Twins On December 1, 2025, Brebbia signed a minor league contract with the
Colorado Rockies that included an invitation to spring training. On March 23, 2026, Brebbia was released by Colorado after failing to make the team's Opening Day roster. On March 29, Brebbia signed a minor league contract with the
Minnesota Twins. He began the season with the Triple-A
St. Paul Saints. == Pitching style ==