Crump studies the diagnosis, management, and prevention of infectious causes of fever in the tropics other than malaria, a complex clinical problem that affects many millions annually particularly in low- and middle-income countries. He has advocated for a comprehensive approach to investigating febrile illness as a necessary progression from the traditional disease-specific approach in tropical medicine. He has contributed to describing the problem of malaria over-diagnosis, and also to appreciation of range of neglected causes of fever including invasive bacterial diseases; bacterial zoonoses such as brucellosis, leptospirosis, Q fever, and rickettsioses; and viral diseases such as Rift Valley Fever. Much of his research is trans-disciplinary involving close collaboration between human health experts, veterinarians, ecologists, and social scientists, and following the so-called '
One Health' approach. Crump serves on the leadership group of the multi-centre international Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE) study that characterizes major preventable and treatable causes of fever in low-resource settings in Africa and Asia. Crump has led the development of reporting standards for disease prevalence and incidence studies, developed hybrid surveillance methods for febrile disease incidence estimation, and has made major contributions on natural history approaches for disease burden assessment. He has led work characterizing the burden of typhoid fever, paratyphoid fever, that has contributed to diagnosis, management, and prevention efforts for these diseases, including vaccine deployment and vaccine development. He has served in a range of advisory roles to the
World Health Organization, including on the burden of invasive salmonelloses to the Foodborne Diseases Epidemiology Reference Group, the
WHO Strategic Advisory Group of Experts on Immunization Working Group on Typhoid Vaccines, and the
WHO Immunization, Vaccines and Biologicals Technical Advisory Group on
Salmonella vaccines. Crump leads work generating and synthesising data to inform country decisions on typhoid prevention by vaccine introduction and non-vaccine measures in endemic areas. Crump has a research interest in global health ethics. He has made major contributions on responsible global health training programs, spurred by concern for the unintended consequences of expansion of short-term global health training opportunities in low-resource areas. With Dr.
Jeremy Sugarman, Crump co-chaired the
Wellcome Trust-funded Working Group on Ethics Guidelines for Global Health Training (WEIGHT) that developed initial guidelines for responsible global health training programs. Crump has developed normative guidance on the responsible scheduling of multiple time zone
teleconferences, and has also written on the value of
cosmopolitan principles and the challenges posed by health
nationalism in global health responses. == Awards and honors ==