On December 22, 1715, at her father's
Green Spring plantation near Williamsburg, John Grymes married Lucy Ludwell (1698-1748), the daughter of wealthy merchant and planter
Philip Ludwell. They had five sons and four daughters, of whom about half survived to adulthood and had children. Their eldest son, Philip Grymes (1721-1762), married Mary Randolph to cement his family's ties to the
First Families of Virginia and succeeded his father both as governor's councilor and as Brandon's owner. Although his namesake son John never reached adulthood (or died at a plantation also named Green Spring in
Louisa County, Virginia in 1749) and Charles died as a boy in 1727, this man hired a painter to portray his youngest sons,
Benjamin Grymes (1725-1774; who moved to Spotsylvania County, which he represented in the House of Burgesses) and Ludwell Grymes (1733-1795). His daughters included: Lucy Ludwell Grymes (1720-1792) who married burgess Carter Burwell and Alice Grymes (1724-1746) who married burgess
Mann Page II, as well as Hannah (who may not have married), and Sarah (who died as an infant). ==Death and legacy==