John Middleton married (contract July 1639), Grizel Durham, a daughter of James Durham of
Pitkerro and
Luffness. She died in September 1666. They had five children together: •
Charles Middleton, 2nd Earl of Middleton (1649/1650–1719), married Lady Catherine Brudenell, daughter of Robert Brudenell, 2nd
Earl of Cardigan, and Ann Savage, had children. • Lady Grizel Middleton, married
William Douglas, 9th Earl of Morton. One child who died in infancy. • Lady Helen Middleton, married
Patrick Lyon, 3rd Earl of Strathmore and Kinghorne. They had eight children. • Two daughters, names not known, who both died in 1669 unmarried and without issue. Middleton's second wife was Lady Martha Carey (1635/6–1706), married 16 December 1667 at St. Andrew's, Holborn, daughter of
Henry Carey, 2nd Earl of Monmouth and his wife
Martha Cranfield. They had two children: • John Middleton (1668–1696). Died unmarried without issue. • Lady Elizabeth Middleton (1672–1748), married William Spelman. They had one child who died young. ==See also==