The seminary's history can be dated from around 1962, when
Mill Hill priest Fr. Kuhn was asked by the bishop of
Kisumu to start a parish in Tindinyo. Fr. Kuhn invited the
Xaverian Brothers from
Mumias to establish their house and serve Tindinyo parish. These brothers built a school, Our Lady of Perpetual Help Secondary School, for form I and II for their aspirants. By around 1968-69 there were hardly any aspirants joining the school, and it was converted into a high school for forms V and VI of St. Peters Minor Seminary. During that time it was unofficially referred to as "Tindinyo College". Among the prominent students of the then Tindinyo college are Bishop
John Oballa Owaa, the ordinary of the
Roman Catholic Diocese of Ngong and the Late Bishop
Linus Okok Okwach, Bishop
Norman King'oo Wambua of Machakos Diocese and Bishop
Mark Kadima Wamukoya ordinary of the
Roman Catholic Diocese of Bungoma. This college was phased out with the introduction of Kenya's
8-4-4 system of education. Meanwhile, the Catholic bishops of Kenya were contemplating beginning a second Theologicum to serve as home for African Christian Theology and
inculturation, and Tindinyo provided a fertile ground for such an enterprise. On 27 January 1989 the new theologicum opened its doors to 79 students, a resident staff of three priests (the founding rector was Fr. Sylvester Sulwe) and served by the Assumption Sisters of Eldoret. It was named after the oldest
Uganda Martyr,
St. Matthias Mulumba Kalemba. On 22 February 1989 the seminary was officially inaugurated by the Apostolic Nuncio to Kenya Archbishop
Clemente Faccani accompanied by all the bishops of Kenya, including Cardinal
Maurice Michael Otunga. Later the Seminary was affiliated to the
Pontifical Urban University in
Rome and was hence able to offer the baccalaureate degree in sacred
Theology in addition to its internal diploma in theology. As from 2023, it is officially affiliated to the Catholic University of Eastern Africa (CUEA). Bishop
Michael Cornelius Otieno Odiwa of the Diocese of Homa Bay was a student in the pioneer class of St. Matthias Mulumba Senior Seminary, Tindinyo. Tindinyo Seminary was temporarily closed on 16 February 2005. It was reopened on 5 August 2005 with 79 theology I students and three resident staff with the Assumption Sisters of Eldoret as supporting staff. The staff comprised Fr. Maurice Muhatia Makumba (later Bishop of Nakuru), Fr. Michael Kamau Ithondeka (Vice Rector and dean of students) and Fr. Edward Kipyegon (spiritual Director and dean of Studies). The seminary was officially inaugurated on August 7, 2005, by Nicodemus Kirima of the Archdiocese of
Nyeri. Later on 4 November 2006, the apostolic nuncio to Kenya
Alain Paul Lebeaupin made an apostolic visit. The Seminary's first Rector was Fr. Sylvester Sulwe. Others include Fathers Benjamin Kiriswa, Patrick Maliti, John Philiph Odero, Boniface Kariuki, Maurice Muhatia Makumba (later Bishop of Nakuru), Dominic Kimengich (later Bishop of Lodwar), Daniel Nakameti, and, , Douglas Mwinja. ==Former students==