Quayle operated a retail butcher business, and later became involved in the construction industry as a homebuilder. He became active in politics as a
Democratic, most notably as a member of Brooklyn's Third Ward Democratic Club. In 1914 Quayle was appointed Deputy Collector of Internal Revenue for New York's first district, and he served until 1919. In addition, during the administration of Mayor
John Francis Hylan, Quayle served as secretary to Frank Mann, deputy commissioner of New York City's Tenement House Department. In 1918, Quayle was chosen as leader of the Democratic organization in part of Brooklyn's 1st District in the
New York State Assembly, and he was a member of the executive committee of the
Kings County Democratic Party. From 1919 to 1923 Quayle was deputy city clerk of New York City, with responsibility for the city clerk's operations in Brooklyn. In 1920, he served as an Alternate Delegate to the
Democratic National Convention. ==Member of Congress==