Spelman married Elizabeth, daughter and coheiress of Henry Frowick (died 1527), of
South Mimms. They had thirteen sons and seven daughters, including: • Henry Spelman (died 1581), second son, who married first Anne, the widow of
Thomas Thursby, daughter of
Thomas Knyvett and his wife Muriel, daughter of
Thomas Howard, 2nd Duke of Norfolk. His second wife was Frances (died 1622), daughter of
William Saunders, of
Ewell, and his first wife Joan Marston. Spelman's widow Elizabeth married secondly John Coningsby, of North Mimms, son of the judge
Humphrey Coningsby, and became the mother of Sir
Henry Coningsby. After her second husband's death in 1547, she married William Dodd and died on 5 November 1556, and was buried at North Mimms. ==References==