On 12 July 1843, Spencer-Churchill married
Lady Frances Anne Emily Vane (15 April 1822 – 16 April 1899), eldest daughter of the
3rd Marquess of Londonderry and
Lady Frances Vane-Tempest. They had eleven children: •
George Charles Spencer-Churchill, 8th Duke of Marlborough (13 May 1844 – 9 November 1892), whose son
Charles Spencer-Churchill, 9th Duke of Marlborough, married into the
Vanderbilt family. • Lord Frederick John Winston Spencer-Churchill (2 February 1846 – 5 August 1850) •
Lady Cornelia Henrietta Maria Spencer-Churchill (17 September 1847 –
Upper Brook Street,
Mayfair, London, 22 January 1927), married 25 May 1868
Ivor Guest, 1st Baron Wimborne, by whom she had issue. •
Lord Randolph Henry Spencer-Churchill (13 February 1849 – 24 January 1895), married 15 April 1874
Jennie Jerome. Their issue included
Sir Winston Churchill and
John Strange "Jack" Spencer-Churchill. • Lady Rosamund Jane Frances Spencer-Churchill (9 November 1851 – 3 December 1920), married 12 July 1877
William Fellowes, 2nd Baron de Ramsey, by whom she had issue. • Lady Fanny Octavia Louise Spencer-Churchill (29 January 1853 – 5 August 1904), married 9 June 1873
Edward Marjoribanks, 2nd Baron Tweedmouth, by whom she had issue. •
Lady Anne Emily Spencer-Churchill (Lower Brook Street, Mayfair, London, 14 November 1854 –
South Audley Street, Mayfair, London, 20 June 1923), married 11 June 1874
James Innes-Ker, 7th Duke of Roxburghe, by whom she had issue. • Lord Charles Ashley Spencer-Churchill (25 November 1856 – 11 March 1858) • Lord Augustus Robert Spencer-Churchill (4 July 1858 – 12 May 1859) • Lady Georgiana Elizabeth Spencer-Churchill (10
St James's Square,
St James's, London, 14 May 1860 – 9 February 1906), married 4 June 1883
Richard George Penn Curzon, 4th Earl Howe, by whom she had issue. •
Lady Sarah Isabella Augusta Spencer-Churchill (4 July 1865 – 22 October 1929), a war correspondent during the
Boer War; married 21 November 1891 Lt. Col.
Gordon Chesney Wilson (son of Sir
Samuel Wilson MP), by whom she had issue. Marlborough died on 4 July 1883, aged 61, and was succeeded in the title by his eldest son, George. His wife died sixteen years later, on 16 April 1899, aged 77. ==Portrayals in film and television==